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Benagene is the world's first shelf-stable oxaloacetate supplement, combining patented thermally stabilised oxaloacetic acid (100mg) with vitamin C (150mg). Vitamin C contributes to the protection of cells from oxidative stress and normal energy-yielding metabolism.
On UK Mainland orders over £50
Benagene represents one of the most significant breakthroughs in nutritional anti-ageing science. At its core is oxaloacetate (OAA), a naturally occurring compound that serves as a key intermediate in the Krebs cycle, the fundamental process by which your body generates cellular energy. While oxaloacetate is found in many foods and is produced continuously by your own metabolism, supplementing with it in sufficient quantities was impossible for decades because the compound degrades rapidly at room temperature, making it too unstable for reliable study or supplementation.
In 2005, Alan Cash, founder of Terra Biological LLC, solved this problem by engineering and patenting a method to thermally stabilise oxaloacetate using Vitamin C, creating Anhydrous Enol Oxaloacetate (AEO). This innovative made Benagene possible: the world's first bioavailable, shelf stable oxaloacetate supplement with a proven two year shelf life. Terra Biological currently holds over 30 patents related to oxaloacetate use and has facilitated dozens of human and animal studies, including multiple clinical trials, investigating its potential.
The science behind Benagene centres on caloric restriction mimicry. Caloric restriction (reducing calorie intake while maintaining nutrition) is the most well-documented method associated with extended lifespan and healthspan in mammals. Research conducted with scientists at UCSD, UCLA, and UC Riverside demonstrated that oxaloacetate supplementation is researched for activating the same molecular pathways as caloric restriction, mimicking up to 98 percent of the changes in genetic expression across over 350 genes, without actually reducing calorie intake. This is remarkable because it means you can potentially access the longevity and health benefits of caloric restriction while eating normally.
The mechanism works through the NAD/NADH ratio. Benagene contributes to the conversion of NADH to its oxidised form, NAD. NAD is a niacin derived coenzyme present in all living cells that is critical to ATP production, your body's source of immediate energy. Higher NAD levels stimulate beneficial genes associated with cellular repair, energy production, and longevity while simultaneously supporting pathways associated with healthy metabolism and ageing. In practical terms, users often report clearer thinking, more sustained energy throughout the day, and improved mental focus.
Each capsule delivers 100mg of thermally stabilised oxaloacetate alongside 150mg of Vitamin C (ascorbic acid), which serves the dual purpose of stabilising the oxaloacetate molecule and providing antioxidant support. The vegan capsule contains nothing else: no fillers, no flow agents, no dyes, no preservatives. This clean formulation reflects Terra Biological's commitment to purity and efficacy.
Beyond energy and longevity, Benagene has shown promise in several other areas of health. Human clinical trials have confirmed its ability to reduce blood glucose levels and improve glucose uptake without negative side effects, making it potentially valuable for those concerned about blood sugar balance. Research also suggests that oxaloacetate has a protective effect on neurons, contributing to mental clarity and normal cognitive function. Additionally, Terra Biological's related product Jubilance (also oxaloacetate) has shown significant improvements in monthly hormonal mood changes and irritability in randomised placebo-controlled clinical trials, suggesting broader mood and hormonal benefits.
Benagene has earned a devoted following among biohackers, longevity researchers, and health professionals. It pairs well with resveratrol supplementation and is a staple in many anti-ageing and performance optimisation protocols. The product is manufactured in state of the art GMP facilities in the United States under strict quality control, with GLP toxicity tests conducted on key ingredients prior to product introduction.
This is a once daily supplement that should be taken with food. It is not suitable for use during pregnancy or lactation. Keep out of reach of children and store in a cool, dry place for best freshness and strength.
The combination of oxaloacetate's neuroprotective properties and vitamin C's contribution to normal psychological function makes Benagene relevant for brain health and cognitive clarity.
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